Acquisitions: - Mankind Pharma, through its Netherlands subsidiary, to acquire a 70% stake in Belgium-headquartered Armed Cell Therapeutics (ACTx), a developer of next-generation “armed” CAR-T cell therapies for cancer, for €48 Million (~INR511.4 crore).
- Laurus Labs signed a term sheet to acquire a 60% stake in Montréal-based Galenvs Sciences, a magnetic nanoparticle and DNA/RNA technology company, for US$3.75 Million, strengthening its oligonucleotide CDMO capabilities.
- Gland Pharma to invest US$21 Million through its US subsidiary for a 60% stake in Novelstar Pharma, a newly formed US entity of the Fosun Pharma group focused on sterile formulations.
- Gilead Sciences to acquire PepStar Therapeutics’ oral IL-23R inhibitor programme, including lead asset HCXT-2001 for inflammatory bowel disease, for US$1.275 Billion in upfront cash.
- Shionogi to acquire US rare disease company IntraBio, maker of Aqneursa (levacetylleucine), for US$2 Billion.
- Viatris to acquire Pacira BioSciences, maker of non-opioid pain therapies Exparel and Zilretta, for about US$1.65 Billion.
- Merck KGaA to acquire UK-based RNAi company Silence Therapeutics for about US$1.3 Billion, adding siRNA candidate divesiran to its pipeline.
- Ferring Pharmaceuticals to acquire fertility biotech Gameto, developer of the Fertilo egg maturation technology, for up to US$1.38 Billion.
- Alcon acquired Neurotech Pharmaceuticals, maker of the approved cell therapy implant Encelto for MacTel, for US$550 Million upfront.
Licensing: - Biocon signed a license agreement with Janssen Sciences Ireland clearing commercialisation of Yesintek (ustekinumab), its Stelara biosimilar, in nine more markets including Australia, Brazil, China, South Korea and Mexico.
- Zylidac Bio, the US biologics subsidiary of Zydus Lifesciences, partnered with Prolific Machines to scale Prolific’s light-controlled biologics manufacturing platform to GMP production.
- Sanofi and Regeneron expanded their antibody alliance to four long-acting IL-13/IL-4 pathway antibodies for type 2 inflammatory diseases, with US$1 Billion upfront and total value of up to US$8 Billion.
- Novartis licensed China-based Abogen’s mRNA-encoded CD19×CD3 T-cell engager ABO2203 for autoimmune diseases, in a deal worth up to about US$7.8 Billion.
- Roche signed a deal worth up to US$813 Million with Zymeworks for ZW209, a DLL3 trispecific T-cell engager for small-cell lung cancer.
Investments/Fund Raising: - Even Healthcare (Bengaluru) raised US$50 Million in a Series B led by Khosla Ventures with Alpha Wave, to expand its hospital network.
- CureBay (rural healthtech) raised about INR100 crore (US$10.6 Million) in a pre-Series C round, with equity led by IvyCap Ventures and debt from Trifecta Capital, Alteria Capital and VentureSoul Partners.
- Clinics On Cloud (Pune, Health ATMs and preventive screening) raised INR120 crore (US$12.5 Million) in a Series A from Dubai-based Model42, at a INR600 crore valuation.
- Peptris Technologies (Bengaluru, AI drug discovery) secured INR86 crore (US$9 Million) from the Technology Development Board (TDB) to take AI-discovered drugs towards clinical trials.
- OMass Therapeutics (UK) raised a US$310 Million Series C led by Bain Capital Life Sciences, with Forbion and Novo Holdings, for its endocrinology and immunology pipeline.
- Pathos AI raised a US$237 Million Series E led by Bristol Myers Squibb at a US$3 Billion valuation, for its AI-driven oncology pipeline.
- Matchpoint Therapeutics raised a US$150 Million Series B to take its oral autoimmune drug MPT-062 into the clinic.
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